The following factors are risk factors for bisphosphonate related jaw bone death bronj the use of intravenous forms of bisphosphonates which have a greater risk factor than the use of oral bisphosphonates though there is still a risk with oral use long term bisphosphonate use extractions or gum surgery naturally sharp bones of the jaw dental infections age concurrent cancer . Whether bisphosphonates affect indirect bone healing is still unclearwe carried out a comprehensive search strategy only randomized controlled trials were included two reviewers independently assessed methodological qualities and extracted outcome . The bisphosphonates not only get inside the bone but they attach very strongly to the bone mineral the different strengths of the bisphosphonates depend on the variations in the side chains notice how similar some of these drugs are to each other click to see a more formal image of bisphosphonate structures
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